The calendar has turned to October and, with it, the race to figure out the contenders and pretenders.
There are 14 games on the docket in Week 5, including a Sunday night game between two of the top teams in the NFL, the 49ers and Cowboys. There’s also another international affair, this time with the Jaguars and Bills squaring off in London.
Here are the matchups that could determine the outcome of each game.
Jacksonville Jaguars (2–2) at Buffalo Bills (3–1)
Key matchup: Jaguars’ pass defense vs. Bills after catch.
Jacksonville has been uneven this year and now takes on an offense averaging 41 points per game over its three-game win streak.
For the Jaguars, the big test is containing Buffalo’s passing game. Jacksonville ranks 31st in yards after catch allowed (548), while the Bills are fifth in the metric offensively (525).






